The 2006 Mercedes-Benz CLK350 is a moderately easy vehicle to maintain, and is recommended to those experienced in vehicle maintenance. The headlight bulb is no problem to change on this vehicle. You only have to reach behind the housing for reliable access to the bulb. Changing the cabin air filter is no problem, as you only have to disengage a few fasteners for access to the filter. These fasteners are easy to disengage. The tail light bulbs are easy to access in the rear of the vehicle. There is a designated access panel that is easy to remove.
Some things are more problematic on the 2006 Mercedes-Benz CLK350. To access the oil drain plug for an oil change you will have to remove many bolts and panels from under the vehicle first. You will have to disengage fasteners and remove a panel for access to the fog light. This will require more steps to complete than usual. Accessing the engine air filter with reliability is more problematic than usual. You will need more tools than usual to complete more steps for access.
Hans Angermeier has produced over 100,000 videos showing drivers how to fix things on their cars. He has broad expertise on basic repair procedures covering the majority of cars on the road.