The 2008 Mercedes-Benz E350 4Matic s a relatively difficult vehicle to maintain and is only recommended to those capable of vehicle maintenance. You will have to remove a large panel from under the vehicle for access to the petcock for a coolant drain. This will require you to contend with gravity as you complete. Changing the engine air filter is more complicated than usual, as you will need to use many tools in order to complete many steps for access. You will have to reach through the wheel well lining for access to the fog light. This lining can grow tight to the vehicle.
Some things are easier on the 2008 Mercedes-Benz E350 4Matic. The components of the spare tire are easily accessible in the rear of the vehicle. This keeps the tire and jack kit ready to go in case of emergency. Checking the oil level with reliability is no problem, as the oil dipstick is easily accessibly in the engine bay. Changing the front turn signal bulb is easy to do, as you only have to reach behind the housing for access to the assembly.
Hans Angermeier has produced over 100,000 videos showing drivers how to fix things on their cars. He has broad expertise on basic repair procedures covering the majority of cars on the road.