The 2013 Ford E-350 Super Duty XLT is a relatively easy van to maintain, and a good choice for the experienced van owner. Checking the transmission fluid level is not a problem, as the dipstick is easily accessible in the engine bay. Not every model includes this dipstick. The engine coolant fluid reservoir is easily visible in the engine bay. This will allow you to reliably check and replenish the fluid level on a regular basis. Changing the engine air filter is easy to do, as you only have to disengage one fastener to access. This fastener is easy to disengage.
Some things are more problematic to repair on the 2013 Ford E-350 Super Duty XLT. You will have to completely remove the headlight housing in order to access the intended bulbs. This will require the removal of a few bolts. Other models make this access less problematic. You will have to lower the spare tire from under the vehicle for access. This can be tough, as the lowering mechanism can grow rusted to the van over time and be difficult to turn. To access the tail light, you will have to remove the housing first. This will require the removal of a few torx bolts, which will require tools you may not have readily available for a repair.
Hans Angermeier has produced over 100,000 videos showing drivers how to fix things on their cars. He has broad expertise on basic repair procedures covering the majority of cars on the road.