The 2013 Mercedes-Benz E350 4Matic is a relatively difficult vehicle to maintain when compared to other similar models. You will have to remove a large panel from under the vehicle in order to access the petcock. This will require you to contend with gravity to complete. Changing the headlight with reliability, as you will have to reach through the wheel well lining for access. This lining can grow tight to the vehicle and be difficult to peel back. The engine air filter is much more complicated to access than usual, as you will need to use additional tools to complete extra steps.
Some things are easier to repair on the 2013 Mercedes-Benz E350 4Matic. The components of the spare tire are easily accessible in the rear of the vehicle. This keeps the tire and jack kit ready to go in case of emergency. The engine coolant reservoir is easily visible in the engine bay. This will allow you to check and replenish the fluid level on a regular basis. Changing the daytime running bulb is no problem. You only have to reach behind the housing for access to the assembly.
Hans Angermeier has produced over 100,000 videos showing drivers how to fix things on their cars. He has broad expertise on basic repair procedures covering the majority of cars on the road.